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KMID : 0387420020130020173
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Korean Society of Oriental Neuropsychiatry
2002 Volume.13 No. 2 p.173 ~ p.194
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The effects of Rhizoma Acori Graminei water extract in Alzheimer’s Disease Model induced by pCT105
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Choi Hyuk
Kim Sang-Ho
Lee Dae-Yong
An Dae-Jong
Kang Hyung-Won
Lyu Yeoung-Su
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Abstract
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Alzheimer’s disease(AD) is a geriatric dementia that is widespread in old age. In the future AD will be the largest problem in public health service. From old times, Much medicines have been used for treatment of dementia, but there is no medicine having obvious effect. AD is one of brain retrogression disease. So We studied on herbal medicine that have a relation of brain retrogression. From old times, In Oriental Medicine, Rhizoma Acori Graminei has been used for disease in relation to brain retrogression. We studied on the effects of anti-Alzheimer in pCT105-induced neuroblastoma cell lines by Rhizoma Acori Graminei extract As the result of this study, In RAG group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuroblastoma cells by CT105 expression is promoted. These results indicate that RAG possess strong inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of Neuroblastoma cells by CT105 expression.
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KEYWORD
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Rhizoma Acori Graminei, Alzheimer’s disease, beta-amyloid precursor protein, carboxyl-terminal 105(CT105), senile plaqu
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